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Shimadzu Corporation Introduces the LCMS-8050 High-Sensitivity, Ultra-Fast Triple Quadrupole LC-MS/MS


Shimadzu Corporation announces the release of the LCMS-8050, a triple quadrupole LC-MS/MS incorporating proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As the high-end model of its UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high sensitivity, high data quality, and the world's fastest data acquisition rates.

Background of Development

To remain competitive, laboratories using LC/MS/MS require higher throughput and reduced costs without sacrificing data quality. In September 2010, Shimadzu Corporation launched the LCMS-8030 triple quadrupole mass spectrometer, which offered the world's fastest scanning speed and polarity switching rate. In May 2012, Shimadzu launched the LCMS-8040, which delivered higher sensitivity while maintaining high-speed performance. Now, to meet the growing demand for trace-level quantitation in clinical research and other markets, Shimadzu launches the LCMS-8050, equipped with advanced high-speed performance and best-in-class sensitivity as the flagship product of the UFMS series.

(1) Unique Product Features

Delivering attogram-level sensitivity and possessing unsurpassed ruggedness, the LCMS-8050 achieves its improved sensitivity through the means of two important technologies:

Newly designed Heated ESI source improves desolvation and enhances ionization efficiency with the addition of a heated gas used in combination with the nebulizer gas.

UFsweeper®III collision cell enhances CID efficiency by optimizing the collision cell pressure.

One common design approach to increase sensitivity in mass spectrometers has been to incorporate a larger inlet to increase the number of ions introduced into the instrument. This approach necessitates the inclusion of a more powerful and more costly vacuum system. However, replacing vacuum pumps is inevitable and expensive, and a larger inlet leads to increased levels of instrument contamination. For these reasons, Shimadzu maintained a smaller inlet in the LCMS-8050. When combined with the new heated ESI source and UFsweeper III, Shimadzu has improved system performance and delivered a rugged LCMS system with a lower cost of ownership.

(2) Advanced UF Technologies

The newly engineered high voltage power supply enables a maximum scan rate of 30,000 u/sec and a 5 msec polarity switching time, making the LCMS-8050 combined with Nexera UHPLC the ideal platform for laboratory productivity. It is now possible to include 1000 events with up to 32 channels per event for a maximum of 32,000 MRMs per analysis.

Maximum Scanning Speed: 30,000 u/sec
Polarity Switching Rate: 5 msec

(3) User-friendly Operation and Easy Maintenance
Newly designed ion source

The new LCMS-8050 ion source is designed to allow easy changing from ESI to APCI or to dual ionization mode (DUIS). The source housing is cable-free and tubeless, integrating the gas and electrical connections for convenience and simplicity.

Seamless integration of HPLC and MS control software

LabSolutions LCMS Version 5.60 for LCMS-8030/8040/8050 provides intuitive, easy-to-use operation. It fully integrates operation of Shimadzu's LC product lines (Nexera and Prominence). An automated MRM optimization routine is provided, allowing unattended optimization of multiple compounds. Key MS voltages, critical to high-sensitivity analysis, are automatically adjusted and evaluated for each compound without user intervention.

Minimized instrument downtime and easy maintenance procedures

The desolvation capillary, which functions as the inlet to the mass spectrometer, can be quickly replaced without breaking vacuum, saving the user hours of recovery time. Probe maintenance is quick and easy, with readily accessible consumable components. Even more advanced maintenance is made simple; ion guides can be removed without tools and cleaned without extensive disassembly.

Shimadzu will show the LCMS-8050 at JASIS (Japan Analytical & Scientific Instruments Show) on September 4-6, 2013, in Makuhari Messe, Chiba, Japan. The LCMS-8050 will also be shown in Portugal on September 2-6, 2013 at the TIAFT conference (The International Association of Forensic Toxicologists), and on September 8-12, 2013 in Indianapolis Indiana, USA, at the ACS (American Chemical Society) exposition.

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